Endocrine Abstracts

Choriogonadotrophin-alpha (Cga) is one of the first molecular markers for the developing pituitary gland previously known as ‘alpha-subunit’, common to thyroid-stimulating hormone (TSH), luteinising hormone (LH) and follicle-stimulating hormone (FSH). Mice lacking Cga are hypogonadal and exhibit profound hypothyroidism and dwarfism. Light microscopy of Cga null mice has shown that pituitary thyrotrophs...

Choriogonadotrophin-alpha (Cga) is one of the first molecular markers for the developing pituitary gland previously known as ‘alpha-subunit’, common to thyroid-stimulating hormone (TSH), luteinising hormone (LH) and follicle-stimulating hormone (FSH). Mice lacking Cga are hypogonadal and exhibit profound hypothyroidism and dwarfism. Light microscopy of Cga null mice has shown that pituitary thyrotrophs...

Background: Prolonged glucocorticoid use is associated with significant morbidity and mortality, including the development of glucocorticoid-induced adrenal insufficiency (GI-AI). There is no consensus regarding glucocorticoid weaning (<5mg prednisolone-equivalent dose) to alleviate withdrawal symptoms while promoting the quickest adrenal axis recovery. There is also limited research into understanding current practice and the barriers to weaning.<p cl...